Moya Moya

The exact cause of Moyamoya disease remains largely unknown, though genetic factors are believed to play a significant role. Mutations in certain genes have been linked to the condition, which can lead to the abnormal development and maintenance of blood vessels in the brain. While rare, environmental factors and certain medical conditions may also contribute to its development.

Moyamoya disease can manifest with a range of neurological symptoms. These may include recurrent transient ischemic attacks (TIAs) or strokes, which can cause sudden weakness, numbness, difficulty speaking, or paralysis on one side of the body. Seizures, headaches, and cognitive impairments, especially in children, can also occur. In advanced stages, individuals might experience more severe strokes leading to significant disability or even death.

Diagnosis of Moyamoya disease involves a combination of clinical evaluation, medical history review, and specialized imaging techniques. Magnetic resonance imaging (MRI) and magnetic resonance angiography (MRA) can reveal the characteristic "puff of smoke" appearance, indicating the narrowed blood vessels in the brain. Cerebral angiography, a more invasive test, is often used to confirm the diagnosis by showing the narrowed arteries and the development of collateral blood vessels that resemble a "moyamoya" pattern.

The primary goal of Moyamoya disease treatment is to prevent strokes and improve blood flow to the brain. Surgical interventions are often employed to achieve this. Revascularization surgeries, such as direct bypass or indirect bypass procedures, aim to provide alternative blood flow pathways to compensate for the narrowed vessels. In some cases, medical management may involve antiplatelet agents to prevent clot formation and antihypertensive medications to manage blood pressure.